Skip to product information
 Rate 4.9/5 Excellent (2,768 Reviews)

R- Alpha Lipoic Acid

R- Alpha Lipoic Acid

Pure R-form alpha lipoic acid, wrapped in coconut oil for real absorption. A full 600mg, taken twice daily to support your nerves at the source.

  • Nerve Cell Support
  • Mitochondrial Antioxidant
  • No Brain Fog
  • Restful Sleep
  • Healthy Energy Support
  • No Prescription Needed

Clinically proven benefits

Backed by clinical research on R-Alpha Lipoic Acid.

  • Supports healthy nerve function in adults*
  • Supports mitochondrial energy production*
  • Provides antioxidant support for cellular health*
  • Pure R-form with enhanced bioavailability for optimal absorption*
  • Made with coconut oil so your body absorbs more of every dose*

Benefits observed in clinical studies of R-Alpha Lipoic Acid when used consistently as part of a healthy lifestyle. Individual results vary.

Why you need Plique R-ALA

If your feet burn at night, you cannot sleep through it, or you are tired of options that leave you foggy while the real problem goes untouched, Plique was made for you.

Most alpha lipoic acid on the shelf is a 50/50 mix, and half of it is the inactive form your body cannot use. Plique is pure R-form at a full 600mg per serving, the form your body actually recognizes, wrapped in coconut oil for real absorption.

One pure R-form antioxidant. One clinical-strength dose. One softgel a day, working for your nerves.

How to use

Take two softgel daily with a meal. That is it. No handful of pills, no complicated routine.

This pure R-form formula works to support healthy nerve function, provide mitochondrial antioxidant protection, and support your nerves at the source, so you can rest easier, move with confidence, and feel clear-headed again.

How long before I see results

Most people notice subtle changes within 3 to 5 weeks of daily use. For full benefits, including improved nerve comfort and sleep quality, consistent use for 2 to 3 months is recommended.

Many customers report feeling better overall in the first month, while nerve-related benefits tend to build more gradually. Because Plique supports your body's natural mitochondrial processes, results are steady and designed to last.

90-day money-back guarantee

If you do not feel a real difference in 90 days, we send every penny back. No forms. No questions.

Sleep through the night, or your money back.

View full details
    • Pure R-Form Only

      The active form your body recognizes. Pure R-(+)-Alpha Lipoic Acid delivers roughly twice the bioavailability of cheap racemic ALA, with no inactive S-isomer and no wasted dose.

    • 600mg Clinical Dose

      The exact dose used in research. Precisely formulated at 600mg per serving, matching the German ALADIN, SYDNEY, and NATHAN clinical trials spanning over 4,000 patients.

    • Nerve Function Support

      Supports healthy nerve signaling. R-ALA crosses the blood-nerve barrier to support healthy nerve function and mitochondrial energy production in peripheral nerve cells.

    • Mitochondrial Antioxidant

      Supports cellular energy production. Naturally rich in antioxidants, R-ALA helps support mitochondrial health and cellular resilience against everyday oxidative stress.

    • Clean & Tested Quality

      Third-party lab tested, made in the USA. Every batch is tested for purity and potency in a GMP-certified facility. Pure R-form, zero S-isomer, no fillers.

      What To Expect

      Your Journey to Calmer Nerves

      Consistency is everything. Here is what most people feel, week by week.

      Weeks 1-2

      Easy Start

      The simplest part of your day.

      • Two softgel a day, taken with a meal
      • No brain fog, no weight gain, no grogginess
      • Gentle on the stomach, easy to stay consistent
      Weeks 3-4

      Support Begins

      The R-ALA reaches where it matters.

      • Crosses the blood-nerve barrier to the mitochondria
      • Many report better, deeper sleep
      • The daily habit starts to feel automatic
      Weeks 5-8

      Comfort You Can Feel

      The stretch most people talk about.

      • Greater comfort in feet and legs reported by many users*
      • Supports healthy nerve signaling and cellular function*
      • Quality-of-life improvements, no withdrawal worries
      Week 8+

      Long-Term Nerve Health

      Where staying consistent pays off.

      • Ongoing nerve and mitochondrial wellness support*
      • Cellular resilience through antioxidant protection*
      • A routine that targets the root cause, not just symptoms

      How It Works

      Support That Reaches Your Nerves

      Your nerves run from your spine to your feet, and that is where the burning and tingling begin. Plique R-ALA crosses the blood-nerve barrier to reach the mitochondria inside your nerve cells, supporting healthy nerve function at the

      Discover Why the German Medical Community Has Used R-ALA Since 1966

      Learn what makes Plique R-Alpha Lipoic Acid different.

      Why Gabapentin Leaves Your Nerves Still Dying, While You Feel Like a Zombie

      Gabapentin does not repair your nerves. It was never designed to.

      It is a sodium-channel blocker, meaning it works by silencing the nerve signal that is screaming at you. The fire is still burning. You just cannot hear the alarm anymore. That is why the brain fog sets in. That is why the weight creeps up. That is why the pain comes roaring back the moment a dose wears off. And that is why, even after months or years on gabapentin, your neuropathy keeps getting worse.

      R-Alpha Lipoic Acid works on an entirely different mechanism. It crosses the blood-nerve barrier, reaches inside the mitochondria of your nerve cells, and neutralizes the oxidative stress that high blood sugar creates. It does not silence the alarm. It puts out the fire.

      • No brain fog, R-ALA does not block signals across your entire nervous system
      • No weight gain, unlike gabapentin and Lyrica, R-ALA is weight neutral
      • No withdrawal, miss a day and nothing happens
      • Addresses the root cause gabapentin ignores

      Plique R-ALA: Real Support for Burning, Tingling Nerves

      For decades, people with diabetic neuropathy have been told the same thing: take gabapentin, control your blood sugar, and learn to live with it.

      Plique offers something different. Each softgel delivers 600mg of pure R-Alpha Lipoic Acid, the exact form and dose used in German clinical trials, formulated with coconut oil for maximum absorption, and designed to support your nerves at the source, not just silence the signal.

      • Supports healthy mitochondrial function in nerve cells
      • Antioxidant support for nerves affected by high blood sugar
      • No brain fog. No weight gain. No withdrawal.

      Pure R-Form. Clinical Dose. Nothing Else.

      Most alpha lipoic acid supplements sold at Walmart and Amazon are a 50/50 racemic mix, half R-form, half S-form. The S-form is a synthetic byproduct that may actually compete with the R-form for absorption.

      Plique uses only pure R-(+)-Alpha Lipoic Acid, the biologically active form your body recognizes, at the full 600mg clinical dose, formulated with coconut oil to maximize bioavailability.

      • 100% pure R-form, zero S-isomer
      • 600mg per serving, matches the ALADIN and SYDNEY trial dose
      • Formulated with coconut oil for enhanced absorption
      • No fillers, no artificial dyes, no unnecessary additives

      Backed by 60 Years of German Prescription Use and 4 Major Clinical Trials

      R-Alpha Lipoic Acid is not a new supplement trend. It was approved as a prescription drug in Germany in 1966 for diabetic neuropathy, nearly 60 years before most American doctors had heard of it.

      The ALADIN, SYDNEY, and NATHAN clinical trials tested it on over 4,000 patients. The results were consistent: a significant reduction in burning, tingling, and numbness, with minimal side effects and no brain fog, no weight gain, no withdrawal.

      It works differently than gabapentin. Instead of blocking the pain signal, R-ALA crosses the blood-nerve barrier, penetrates the mitochondria inside your nerve cells, and neutralizes the oxidative stress that high blood sugar creates, addressing the root cause, not just the symptom.

      • German prescription drug since 1966
      • 4 major clinical trials, 4,000+ patients
      • Crosses the blood-nerve barrier and penetrates the mitochondria
      • Backed by our 90-day money-back guarantee

      Unlike Gabapentin, Plique Supports Your Nerves at the Source

      Formulated with pure R-form alpha lipoic acid to support healthy nerve function, mitochondrial energy, and everyday antioxidant protection. It uses only the biologically active R-(+) form, none of the inactive S-isomer that blocks absorption in ordinary ALA, so more of every dose reaches your nerves.

      Try Plique Today

      The Difference

      Plique vs Other Brands

      Plique R-Alpha Lipoic Acid
      Plique
      Other Brands
      Pure R-Form Only
      The kind your body actually uses
      Cheap 50/50 Mix
      Half goes to waste
      600mg Clinical Dose
      The amount that makes a difference
      Under-Dosed
      Often 100 to 300mg
      Coconut Oil Absorption
      Absorbs into your bloodstream
      Passes Through You
      Most of it never absorbs
      Third-Party Tested
      Purity and potency verified
      No Transparent Testing
      You just have to trust it
      Two Softgel A Day
      Easy to remember
      Two Or More Pills
      A bigger daily habit
      Made with coconut oil so more of every dose gets absorbed
      Most people feel a difference in 3 to 5 weeks, not months of guessing
      Built for real nerve support, not short-term symptom masking
      Try Plique Risk-Free Today

      90-Day Money-Back Guarantee. If you do not feel a difference, you pay nothing.

      Before You Ask

      We're serious about nerve health. Ask away.

      Honest answers to the questions we hear most.

      This is the most common thing we hear, and there is a real reason it did not work.

      Almost every ALA supplement sold at Walmart, Amazon, or the big chains is a 50/50 "racemic" mix of two mirror-image forms: the R-form and the S-form. Only the R-form is biologically active, it is the one your body makes naturally. The S-form is a synthetic byproduct that does nothing, and it can actually compete with the R-form for absorption, blocking it from getting in.

      So if you took regular ALA and felt nothing, you were likely absorbing a fraction of an already under-dosed pill. Plique is 100% pure R-form at the full 600mg, wrapped in coconut oil so far more of every dose actually reaches you.

      We understand the skepticism, and we will not promise you overnight results.

      Most people notice a difference in burning, tingling, and numbness within 3 to 5 weeks. Some feel changes in the first week or two. Others take the full 8 weeks. The key is consistency, R-ALA works gradually by supporting your nerve cells from the inside, and that process takes time.

      We recommend committing to at least 8 weeks. That is why every order is backed by a 90-day money-back guarantee, so you have the full time it needs, with zero financial risk.

      This is completely understandable, and the answer has nothing to do with whether it works.

      R-Alpha Lipoic Acid has been used in Germany as a prescription treatment for nerve health since 1966. German doctors have relied on it for nearly 60 years. But in the United States it has never gone through the FDA drug-approval process, not because it is unsafe or ineffective, but because it is a naturally occurring compound that cannot be patented.

      No patent means no company will spend hundreds of millions on approval trials, and no approval means no sales reps introducing it to your doctor. Your doctor is not withholding anything. They were simply never trained on a compound no one profits from teaching.

      Two softgel daily with a meal. That is it. No handful of pills, no complicated routine. Taking it with food helps absorption.

      R-Alpha Lipoic Acid on its own is water-soluble, so a lot of it passes straight through you. Coconut oil makes it fat-soluble, so it crosses into your bloodstream and actually reaches your nerves. That is what makes Plique roughly twice as bioavailable as standard ALA.

      R-ALA is generally very well tolerated and fits easily into most daily routines.

      The main thing to be aware of: if you take insulin or diabetes medication, R-ALA can affect blood sugar, so your doctor may want to monitor your levels. We always recommend letting your doctor know you are adding R-ALA, most will have no objection.

      Never stop or reduce a prescription medication without consulting your doctor first.

      One active: pure R-Alpha Lipoic Acid at 600mg. Other ingredients are coconut oil, gelatin, glycerin, and purified water. It is non-GMO, gluten-free, third-party lab tested, and made in a GMP-certified facility in the USA. No fillers, no artificial dyes.

      We offer a full 90-day money-back guarantee, no fine print, no hoops to jump through.

      Here is why we are confident enough to offer it: R-ALA has decades of safety behind it and a long clinical track record. We have formulated it at the exact dose and purity that track record is built on. If you take it consistently for 8 weeks and do not feel a real difference in your burning, tingling, or sleep, contact us for a full refund. No questions asked.

      We would rather earn your trust than keep your money.

      • 5 stars: 25 (100%)
      • 4 stars: 0 (0%)
      • 3 stars: 0 (0%)
      • 2 stars: 0 (0%)
      • 1 star: 0 (0%)
      S
      Sarah M.
      My 3pm crash is officially gone.

      Two weeks in and I actually have energy left at dinner time. Small softgels, no aftertaste. No complaints at all.

      N
      Nancy O.
      Tiny softgels, big difference.

      I hate swallowing pills and these go down like nothing.

      J
      James T.
      Fast shipping, zero fuss.

      Ordered Monday, in my mailbox Thursday. Packaged well, fresh product, no issues whatsoever.

      K
      Karen D.
      Energy for grandkid duty!

      I pick the grandkids up from school three days a week and this keeps me going. I keep a bag in the car so I never miss a day.

      E
      Elizabeth V.
      Good product, quick delivery

      Arrived faster than expected. Softgels are fresh, no odd smell. Three weeks in and I do feel a bit more energetic. Will update at the two-month mark.

      A
      Anthony B.
      No more mid-morning slump

      One softgel before my commute and my energy stays level all morning. I also appreciate that it's gluten-free and third-party tested. That matters to me.

      M
      Michael S.
      Easy on the stomach, real energy

      A lot of supplements upset my stomach, but these softgels go down easy even first thing in the morning with just coffee. I've been taking one daily for over a month now and my energy doing yard work and house projects is noticeably better. No jitters, no crash — just steady.

      T
      Thomas E.
      71 and sharper than I've felt in years

      At my age you pay attention to what you put in your body, and this has been a great addition to my routine. I take it with breakfast and I've noticed a real boost in mental clarity through the day. The resealable bag keeps everything fresh, and one softgel a day is the easiest habit I've ever kept.

      R
      Richard P.
      Good quality, one small wish

      Morning softgel on the porch has become a ritual. Clean formula, no fillers, third-party tested — that's what sold me. My only wish is a larger count option, since I go through a bag about every two months. Otherwise no complaints.

      R
      Robert K.
      Solid product after years of ALA use

      I've taken alpha lipoic acid on and off for years, mostly for nerve support, and I switched to this brand specifically because of the 600mg dose and the pure R-form. Most of what you find in stores is the cheaper 50/50 racemic mix, and honestly after reading about it I didn't want half my dose to be the form my body can't even use. So far this has been great — steady energy, no stomach issues, and the softgels are genuinely small and easy to swallow. My only tiny gripe is that the reseal strip on the bag can be a little finicky once your hands are oily from cooking, but that's me reaching for a complaint. Genuinely happy with the switch.

      D
      David H.
      Third bag — here's why I keep coming back

      This is my third order of the R-alpha lipoic acid and I figured it was time to leave a proper review. I spent weeks researching before my first purchase because I wanted to understand the difference between regular ALA and the R-form — turns out most store brands are a racemic mix, meaning half of every pill is the inactive S-isomer your body can't use. Plique is pure R-form, which is roughly twice as bioavailable, and the coconut oil wrapping means even more of it actually reaches your bloodstream instead of passing straight through. I've been consistent for about five months now. My energy is more stable through the day, my recent blood work came back looking great (my doctor actually asked what I'd changed), and I no longer hit that wall around 3pm. The quality is obvious — fresh softgels, clean label, third-party tested, made in the USA. If you're on the fence, commit to at least two months. It builds gradually, but it's worth it.

      P
      Patricia W.
      Skeptical at first, believer now

      I'll admit I was fully prepared to be disappointed. I've tried more supplements than I can count that promised energy and delivered nothing, so I half expected this to be another bag gathering dust in my cabinet. I was wrong. It took about two and a half weeks before I noticed anything, but once it kicked in it was unmistakable — my evening energy came back, I'm sleeping more deeply, and I wake up feeling like I actually rested. The softgels are tiny compared to the horse pills other brands sell, and there's no aftertaste, which was a pleasant surprise. I take mine with dinner every night and it's become such an automatic habit that I packed them for a family trip without even thinking about it. Two months in now and I'm a genuine convert. If you're skeptical like I was, give it the full 8 weeks before you judge it. It works gradually, but the change is real.

      D
      Daniel W.

      Feet don't tingle anymore. Enough said.

      K
      Kevin R.
      Five stars, simple as that.

      Does exactly what it promises. One softgel, done.

      D
      Deborah F.
      Grateful for this little bag of goodness!

      My joints feel better and I've got my pep back. Told my sister about it and she ordered the same day. Easy to swallow, no stomach upset.

      S
      Steven C.
      Recovery feels noticeably faster

      I lift four times a week and started this for antioxidant support. Soreness between sessions is way down and my energy during workouts is steadier.

      B
      Brian M.
      Back on the course!

      Joint stiffness had me benched. Two months of R-ALA and I'm playing 18 holes again with the guys. Can't argue with results.

      S
      Susan L.
      Good so far

      About ten days in. No side effects, easy to swallow, haven't felt a big shift yet but supplements take time. Quality seems legit.

      C
      Carol B.
      Five stars from me

      A friend recommended Plique and she was right. Ordering was easy, delivery was quick, and I genuinely feel more vibrant week over week.

      B
      Barbara N.
      The R-form makes a real difference

      I switched from a big-name store brand and the difference is honestly real. This is the R-form, which absorbs better than the regular mix you find everywhere, and I can feel it. My energy is steadier and my skin even looks brighter, which was a nice surprise I wasn't expecting.

      J
      Jennifer P.
      Clean label, real results

      I'm the type who reads every single ingredient, so I love that this is non-GMO, gluten-free, no fillers, and made with coconut oil for absorption. My energy during WODs has improved and recovery feels smoother. I liked the first bag enough that I've already subscribed to monthly deliveries.

      M
      Mary J.
      Approved by my nutritionist

      I've been monitoring my blood sugar and adding R-ALA has been part of a genuinely positive trend alongside my diet changes. My nutritionist looked over the label and gave this brand the green light — pure R-form, clinical 600mg dose, and the coconut oil base for absorption. Glad I found it.

      L
      Linda G.
      My doctor suggested it, and she was right

      My doctor recommended alpha lipoic acid to me a few months back after I kept mentioning afternoon fatigue and tingling in my feet. I did a lot of homework before choosing a brand — I wanted the R-form specifically because that's the active one your body actually recognizes, and the 600mg clinical dose matched what the research used. Two months in, I can honestly say I feel better overall than I have in a while. My energy through the afternoon is steadier, the evening tiredness isn't crushing me anymore, and the tingling has eased up. I also love the coconut oil base because I read that fat-soluble delivery makes a real difference in how much actually gets absorbed. The softgels are small, there's no weird aftertaste, and taking one a day with breakfast is the simplest routine I've ever stuck to. I'll be reordering.

      G
      George F.
      Slow and steady wins — a realistic take

      I started taking this on my doctor's advice and I want to give an honest, realistic review because I think some people expect miracles overnight. That's not how this works. The first two weeks, I honestly didn't feel much of anything. Around week four, I started noticing my energy holding steadier through the afternoon instead of dropping off a cliff. By week seven or eight, both my energy and general mood had improved in a way I can only describe as steady — not dramatic, not a jolt, just consistently better. The quality is excellent: pure R-form, clean ingredients, lab tested, made in the USA. The softgels are small and I've never had any stomach discomfort, even taking it with just breakfast and coffee. I'd say give it the full two months the brand recommends before judging results. It builds gradually because it's actually supporting your cells rather than masking anything. That's exactly what I wanted, and I'm sticking with it.

      W
      William A.
      Worth every penny — cheaper ALA doesn't compare

      I want to address the price question because I had the same hesitation. Yes, you can find alpha lipoic acid cheaper at the big-box stores — I've bought those too. Here's the thing: those cheap options are almost always the racemic 50/50 mix, so half of every capsule is the inactive form that may actually compete with the good stuff for absorption. Then most of them are water-soluble with no fat carrier, so a big chunk of what you do absorb just passes through you. When I did the actual math on effective dose per dollar, this stopped looking expensive. Since switching, the difference has been clear: my afternoon brain fog is basically gone, my energy is smoother through the whole day, and the 600mg clinical dose in one softgel means I'm not juggling multiple pills. This is my second order and it's earned a permanent spot in my daily routine. Pay for the form that actually works.